Spatiotemporal transcriptomic characteristics of immune and metabolic dysregulation during mouse brain aging.

Minghao Qin, Xuanwen Jin, Yuheng Yang, Fengcongzhe Gong, Jin Wan, Jiawen Wei, Baofa Sun, Xueying Li, Yajuan Hao

Department of Urology, Shanghai Tenth People's Hospital, Tongji University, Shanghai, 200072, China.Department of Urology, Shanghai Tenth People's Hospital, Tongji University, Shanghai, 200072, China. · pubmed

Paper

Abstract

Aging and its associated neurodegenerative diseases were increasingly recognized as one of the greatest global health threats. Brain aging involved a multitude of pathological changes, including immune inflammation and metabolic dysregulation.

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper investigates the spatiotemporal transcriptomic changes associated with immune and metabolic dysregulation during brain aging. This research is relevant as it addresses underlying mechanisms of aging and potential pathways that could be targeted for interventions in age-related diseases.

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