Obstructive sleep apnea and aging of the cardiovascular system: a multidimensional analysis of the mechanisms involved.

Xiaolin Hao, Yan Li, Xiaoling Gao

Department of the Second Clinical Medicine, Shanxi Medical University, Taiyuan, Shanxi, China.Department of the Second Clinical Medicine, Shanxi Medical University, Taiyuan, Shanxi, China. · pubmed

Paper

Abstract

Emerging evidence has revealed a strong association between obstructive sleep apnea (OSA) and aging. Considering the critical role of the cardiovascular system, this review explores the key mechanisms linking OSA to cardiovascular aging through a focus on chronic intermittent hypoxia (CIH) -induced oxidative stress and chronic inflammation. Specifically, we examine six key pathways: (1) cellular senescence, (2) mitochondrial dysfunction, (3) metabolic dysregulation, (4) telomere attrition, (5) impaired intercellular communication, and (6) adipose tissue senescence. These insights provide a foundation for identifying novel interventions and therapeutic targets to mitigate or even reverse cardiovascular aging.

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper claims that obstructive sleep apnea contributes to cardiovascular aging through mechanisms like oxidative stress and inflammation. This research is relevant as it explores underlying mechanisms of aging, potentially leading to interventions that address root causes of cardiovascular aging.

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