The Metabolic Transition Between Fasting and Feeding Alters Aging-Associated Metabolites, Lowers BCAAs, and Stimulates FGF21 Production in Humans.

Maria Lastra Cagigas, Nancy T Santiappillai, Serena Commissati, Giovanni Fiorito, Andrius Masedunskas, Gayathiri Rajakumar, Isabella de Ciutiis, Alan Goldhamer, Brian K Kennedy, Andrew J Hoy, Luigi Fontana

Charles Perkins Centre, Faculty of Medicine and Health, The University of Sydney, Camperdown, Australia.Charles Perkins Centre, Faculty of Medicine and Health, The University of Sydney, Camperdown, Australia. · pubmed

Paper

Abstract

Fasting-based interventions are gaining momentum as strategies to modulate longevity. Conversely, the same metabolic adaptations that once ensured survival during starvation now contribute to the global obesity epidemic. While previous studies have characterized metabolic changes during fasting, few have examined the refeeding phase, and most lack an integrated analysis of key hormonal and metabolic regulators, including insulin, leptin, adiponectin, free T3, FGF21, and the plasma metabolome. To address this gap, we profiled 134 plasma metabolites using mass spectrometry, covering pathways involved in lipid, amino acid, and ketone metabolism, in a cohort of 20 adults (mean age 52.2 ± 11.8 years, 55% women, BMI 28.8 ± 6.4 kg/m

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Research summary

The paper claims that the metabolic transition between fasting and feeding alters aging-associated metabolites and stimulates FGF21 production in humans. This research is relevant as it explores metabolic adaptations that could influence aging processes and longevity, focusing on the interplay between fasting and refeeding phases.

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