A paradoxical role of autophagy: promoting protein aggregates and hindering rejuvenation in a

Yuxiang Huang, Daniel J Klionsky

Life Sciences Institute and Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI, USA. · pubmed

Paper

Abstract

Macroautophagy (hereafter referred to as autophagy) is widely recognized as a central pathway for the clearance of protein aggregates and the maintenance of proteostasis. However, a recent study by Murley et al. challenges this conventional view. Using a

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper claims that autophagy may paradoxically promote protein aggregates and hinder rejuvenation. This research is relevant as it challenges existing paradigms about autophagy's role in aging and proteostasis, potentially addressing mechanisms that contribute to the aging process.

Author of this paper? Send a correction.