HLA-DRB1*15:01 is associated with a reduced likelihood of longevity in northern European men.

Nicolás Mendoza-Mejía, Daniel Kolbe, Onur Özer, Janina Dose, Guillermo G Torres, Andre Franke, Marianne Nygaard, Almut Nebel

Institute of Clinical Molecular Biology, Kiel University, University Hospital Schleswig-Holstein, Kiel, Germany.Institute of Clinical Molecular Biology, Kiel University, University Hospital Schleswig-Holstein, Kiel, Germany. · pubmed

Paper

Abstract

Prior research on the genetics of human longevity has identified only a few robust associations. While these studies highlight the importance of metabolic processes for longevity, the contribution of immune genes, specifically those in the highly polymorphic human leukocyte antigen (HLA) region, remains understudied. Here, we addressed this gap by analysing the influence of HLA variation on longevity in Europeans.

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Research summary

The paper claims that the HLA-DRB1*15:01 allele is associated with a reduced likelihood of longevity in northern European men. This research is relevant as it explores the genetic factors influencing longevity, specifically focusing on immune genes, which may contribute to understanding the biological mechanisms underlying aging.

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