Intermuscular adipose tissue in healthy human aging - effects of exercise training and implications to metabolic health.
Abstract
Intermuscular adipose tissue (IMAT) is an anatomically distinct depot that is associated with metabolic dysfunction and aging. IMAT decreases with exercise in older adults with obesity, but less is known about how exercise influences IMAT in healthy, non-obese older adults in relation to insulin sensitivity. The purpose of this study was to determine if lower leg IMAT accumulates in healthy older adults in the absence of obesity, diabetes, or frailty and its relationship to insulin sensitivity. We also determined the influence of exercise training on lower leg IMAT. 29 young (25.0 ± 3.7 years) and 22 older (70.0 ± 4.0 years) adults underwent MRI-based measurements of lower leg IMAT and insulin sensitivity measurements by hyperinsulinemic euglycemic clamp before and after 12 weeks of exercise training. IMAT was higher in older compared to young adults (521 ± 217 mm
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Research summary
The paper claims that lower leg intermuscular adipose tissue (IMAT) accumulates in healthy older adults and that exercise training can influence this accumulation and its relationship to insulin sensitivity. This research is relevant as it explores the relationship between a specific adipose tissue depot and metabolic health in aging, potentially addressing underlying mechanisms of metabolic dysfunction associated with aging.
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