Dendrobine ameliorates mitophagy-mediated endothelial senescence in diabetic kidney disease through activating the SIRT1/FOXO3a pathway.

Yan Zhang, Xuan Qi, Rui-Xuan Sun, Yong-Fang Gong, Hong-Kai Yang, Wu-Ling Wang, Yan Yang, Yong-Sheng He, Yu-Sheng Shi

Ma'anshan People's Hospital, Ma'anshan, 243000, China. · pubmed

Abstract

Glomerular senescence plays a vital role in the pathogenesis of diabetic kidney disease (DKD). Dendrobine (Den) exhibits anti-senescence properties and nephroprotective effects; however, its precise impact and underlying mechanisms in ameliorating glomerular senescence in DKD remain unclear.

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

Dendrobine ameliorates endothelial senescence in diabetic kidney disease by activating the SIRT1/FOXO3a pathway. The paper addresses mechanisms related to cellular senescence, which is a key aspect of aging and age-related diseases, thus contributing to the understanding of longevity.

Author of this paper? Send a correction.