Resistance training enhances metabolic and muscular health and reduces systemic inflammation in middle-aged and older adults with type 2 diabetes: a meta-analysis.

Jingwen Wang, Shiqian Fan, Jianshe Wang

School of Physical Education, Henan Normal University, Xinxiang, Henan, 475100, China. Electronic address: [email protected] of Physical Education, Henan Normal University, Xinxiang, Henan, 475100, China. Electronic address: [email protected]. · pubmed

Paper

Abstract

This meta-analysis evaluated the effects of resistance training on insulin resistance, muscle function, and systemic inflammation in middle-aged and older adults (aged 50 years and older) with type 2 diabetes mellitus (T2DM). PubMed, Web of Science, Scopus, and Cochrane CENTRAL were systematically searched from their inception to May 20, 2025. Forty-three randomized controlled trials (n = 2012 (55.8 % women); mean age 57.8 ± 8.4 years; mean BMI 30.9 ± 3.8 kg/m

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Research summary

Resistance training improves metabolic and muscular health while reducing systemic inflammation in middle-aged and older adults with type 2 diabetes. The paper is relevant as it addresses interventions that may enhance healthspan and mitigate age-related metabolic decline, which are critical aspects of longevity research.

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