Cistanche deserticola extract and its active components, echinacoside, ameliorate sarcopenia by activating the IGF-1/PI3K-AKT pathway to modulate ferroptosis.

Xiaomin Wang, Liping Zhu, Ruoyutong Du, Ang Li, Na Li, Xiaoying Liu, Yin Zhang, Xiaoqin Liu, Qiong Wang, Chao Han, Chao Qu, Wei Zou, Jing Liu, Yanfu Wang

Department of General Medicine, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China; Dalian Medical University, Dalian, Liaoning, China.Department of General Medicine, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China; Dalian Medical University, Dalian, Liaoning, China. · pubmed

Paper

Abstract

Sarcopenia (SP) is characterized by progressive loss of skeletal muscle mass and function, and is a significant health burden in an aging society. Existing therapies have limited effectiveness. While ferroptosis plays a key role in sarcopenia, its regulatory mechanism remains unclear. As a traditional tonifying Chinese medicine, Cistanche deserticola has antioxidant potential due to its active ingredient, echinacoside (ECH); however, its mechanism of action in sarcopenia remains to be elucidated.

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Research summary

Cistanche deserticola extract and echinacoside may improve sarcopenia by activating the IGF-1/PI3K-AKT pathway to modulate ferroptosis. This research addresses a significant age-related condition, sarcopenia, and explores potential mechanisms that could contribute to healthier aging.

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