Upregulation of senescence-associated gene expression levels in human gingival tissue affected by periodontitis.

Su Jung Kim, Chandni Batra, Hiroki Yoshii, Yusuke Hamada, Yasuyoshi Ueki, George J Eckert, Vanchit John, Mizuho Kittaka

Department of Periodontology, Indiana University School of Dentistry, Indianapolis, Indiana, USA.Department of Periodontology, Indiana University School of Dentistry, Indianapolis, Indiana, USA. · pubmed

Paper

Abstract

Accumulation of senescent cells is increasingly recognized as a mechanism of aging and is considered an attractive therapeutic target for various age-associated diseases. The prevalence and severity of periodontitis increase with age, and preclinical studies have demonstrated that senescent cells could be a potential therapeutic target for age-associated periodontitis. However, clinical data linking cellular senescence and periodontitis are limited.

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Research summary

The paper claims that senescence-associated gene expression levels are upregulated in human gingival tissue affected by periodontitis. This research is relevant as it explores the link between cellular senescence and periodontitis, a condition that worsens with age, potentially addressing a root cause of age-related diseases.

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