MRI-based multi-organ clocks for healthy aging and disease assessment.

Huizi Cao, Zhiyuan Song, Michael R Duggan, Guray Erus, Dhivya Srinivasan, Ye Ella Tian, Wenjia Bai, Michael S Rafii, Paul Aisen, Daniel W Belsky, Keenan A Walker, Andrew Zalesky, Luigi Ferrucci, Christos Davatzikos, Junhao Wen

Laboratory of AI and Biomedical Science (LABS), Columbia University, New York, NY, USA.Laboratory of AI and Biomedical Science (LABS), Columbia University, New York, NY, USA. · pubmed

Paper

Abstract

Biological aging clocks across organ systems and tissues have advanced understanding of human aging and disease. In this study, we expand this framework to develop seven magnetic resonance imaging-based multi-organ biological age gaps (MRIBAGs), including the brain, heart, liver, adipose tissue, spleen, kidney and pancreas. Using data from 313,645 individuals curated by the MULTI Consortium, we link the seven MRIBAGs to 2,923 plasma proteins, 327 metabolites and 6,477,810 common genetic variants. Genome-wide associations identify 53 MRIBAG-locus pairs (P < 5 × 10

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Research summary

The study claims to develop MRI-based biological age gaps across multiple organs to assess healthy aging and disease. This research is relevant as it aims to enhance understanding of biological aging mechanisms, which could contribute to addressing the root causes of aging and age-related diseases.

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