Aging Accelerates Degradation of Human Neuromuscular Junction Following Peripheral Nerve Injury.

Luigi P Gonzales, Vivian Y Chen, Amanda Tedesco, Saman Andalib, Chris Lee, David J Wright, Tyler R Johnston, Tahseen Mozaffar, Oswald Steward, Ranjan Gupta

Department of Orthopaedic Surgery, University of California, Irvine, Irvine, California, USA. · pubmed

Paper

Abstract

Clinical observations indicate differences between young versus older adults in outcomes of peripheral nerve injury (PNI). Here, we present an analysis of motor endplates (MEPs) from normal and denervated deltoid muscle biopsies from young adult (≤ 60 years) and older (> 60 years) patients.

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Research summary

Aging accelerates the degradation of neuromuscular junctions following peripheral nerve injury in older adults. This study addresses the biological mechanisms underlying age-related changes in neuromuscular function, which is pertinent to understanding the aging process and its impact on recovery from injuries.

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