Nuclear entry of AS160 as a transcriptional regulator of satellite cells for muscle regeneration.

Xinyu Yang, Ye Cao, Yuwei Zhou, Qing Yao, Ping Rong, Xu Wang, Qiaoli Chen, Weikuan Feng, Li Zhang, Heng Ai, Dahai Zhu, Lei Fang, Tong-Jin Zhao, Xinhua Ye, Hong-Yu Wang, Shuai Chen

State Key Laboratory of Pharmaceutical Biotechnology, Department of Endocrinology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Model Animal Research Center, Nanjing University, Nanjing, China. · pubmed

Paper

Abstract

Dysfunction of muscle satellite cells is linked to diabetic myopathy. The mechanisms vitiating muscle satellite cell proliferative activity in diabetes are not well understood. Here, we show that AS160, a key cytosolic Rab-GTPase activating protein (RabGAP) in insulin signaling, is a moonlighting protein regulating muscle satellite cell proliferation as a transcriptional co-factor. Deletion of AS160, but not its GAP-inactive mutation, impairs muscle satellite cell proliferation and consequent muscle regeneration, and exacerbates age-related sarcopenia. Mechanistically, Thr

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Research summary

AS160 regulates muscle satellite cell proliferation and muscle regeneration, which is crucial for addressing age-related sarcopenia. The paper explores mechanisms that could potentially mitigate age-related decline in muscle function, linking it to the broader context of aging and longevity.

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