The geroprotective potential of chalcones.

Didac Carmona-Gutierrez, Andreas Zimmermann, Guido Kroemer, Frank Madeo

Institute of Molecular Biosciences, NAWI Graz, University of Graz, Graz, Austria. [email protected]. · pubmed

Abstract

Aging is the most important risk factor for multiple pathologies including cardiovascular, neoplastic, metabolic and neurodegenerative diseases. Potential geroprotective strategies involve lifestyle-related, nutritional and pharmacological interventions. Recently, chalcones, a subgroup of secondary plant metabolites, have gained attention. 4,4'-dimethoxychalcone was the first chalcone to be shown to mediate geroprotection and lifespan extension across different species. Several other chalcones also exert anti-aging effects at the cellular and organismal levels. Defined mechanistic routes that are causally involved in these protective effects have been delineated. Here, we summarize current evidence supporting the potential of 4,4'-dimethoxychalcone and other chalcones as geroprotective agents.

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Research summary

Chalcones, particularly 4,4'-dimethoxychalcone, have potential geroprotective effects that may extend lifespan across different species. The paper discusses mechanisms that could address the root causes of aging, making it relevant to longevity research.

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