Slowing down to take it in: Endocytosis during cellular aging.
Abstract
Aging cells functionally decline and accumulate damage through poorly understood mechanisms. In this issue, Antentor et al. (https://doi.org/10.1083/jcb.202412064) find that increased vacuolar pH in older yeast cells slows clathrin-mediated endocytosis. These findings have broad implications in aging-related plasma membrane protein quality control.
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Research summary
Increased vacuolar pH in older yeast cells slows clathrin-mediated endocytosis. This study addresses a mechanism related to cellular aging, contributing to the understanding of aging processes and potential interventions in age-related cellular decline.
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