Biochanin A alleviates endothelial cell senescence via epigenetic regulation of the HDAC1/H3K4me3/NFKB1 axis.

Xiaoying Wang, Qiang Tu, Aiqiu Mao, Kun Meng, Jun Lv, Bo Li, Tangya Zhang, Hui Zhang, Yan Ding, Zheng Cao

Department of Cardiology, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei 442000, China; Institute of Infection and Immune Diseases, Hubei Key Laboratory of Embryonic Stem Cell Research, Hubei Provincial Clinical Research Center for Umbilical Cord Blood Hematopoietic Stem Cells, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, Hubei, China.Department of Cardiology, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei 442000, China; Institute of Infection and Immune Diseases, Hubei Key Laboratory of Embryonic Stem Cell Research, Hubei Provincial Clinical Research Center for Umbilical Cord Blood Hematopoietic Stem Cells, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, Hubei, China. · pubmed

Paper

Abstract

Aging is a multifaceted physiological and pathological process, with endothelial cell senescence being a pivotal contributor to vascular aging. Biochanin A (BCA), a naturally occurring flavonoid, possesses known anti-inflammatory and antioxidant properties; however, its specific role and mechanism in combating endothelial senescence are not well defined.

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Research summary

Biochanin A alleviates endothelial cell senescence through epigenetic regulation. The study addresses a mechanism related to endothelial cell aging, which is a key factor in vascular aging and longevity.

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