Precise gene editing of pathogenic Lamin A mutations corrects cardiac disease.

Xurde M Caravia, Brian Hayashi, Hui Li, Peiheng Gan, Damir Alzhanov, Wei Tan, Kenian Chen, John R McAnally, Lin Xu, Ning Liu, Eric N Olson

Department of Molecular Biology, Hamon Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390. · pubmed

Paper

Abstract

Mutations in the Lamin A (

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Research summary

The paper claims that precise gene editing can correct pathogenic Lamin A mutations to alleviate cardiac disease. This research addresses the underlying genetic causes of a specific age-related condition, potentially contributing to longevity by targeting mechanisms of cellular aging.

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