Amino acid metabolic signatures of dynapenic obesity in older adults: a (principal component analysis) PCA-based sex-stratified analysis in the Bushehr elderly health program.

Maryam Kheirandish, Neda Cheraghloo, Nafiseh Tavasoli, Farideh Razi, Farima Farsi, Atefeh Amrollahi Bioky, Hamid Reza Aghaei Meybodi, Kazem Khalagi, Ramin Heshmat, Niloufar Najjar, Maryam Amini Shirkouhi, Iraj Nabipour, Gita Shafiee, Bagher Larijani

Department of Endocrinology, School of Medicine, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran. · pubmed

Paper

Abstract

Dynapenic obesity (DO), the co-occurrence of muscle strength loss and obesity in aging adults, exacerbates metabolic dysfunction and disability risks. While amino acid (AA) dysregulation is implicated in both conditions, their combined metabolic signature remains unexplored. We aimed to identify sex-specific amino acid metabolic patterns associated with DO in Iranian older people.

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Research summary

The paper identifies sex-specific amino acid metabolic patterns associated with dynapenic obesity in older adults. This research is relevant as it explores metabolic dysregulation in aging, which could contribute to understanding and potentially addressing the underlying mechanisms of age-related decline.

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