α-Lipoic acid mitigates age-related cognitive decline by modulating PPARγ/NF-κB-mediated neuroinflammation.

Zhenyuan Zhang, Cong Zhang, Yuan Zhao, Ya Gao, Yidan Zhang, Lan Zhang, Yutong Zheng, Xiangjian Zhang, Guofeng Yang, Jian Zhang

Department of Geriatrics, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei 050000, PR China; Department of Neurology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei 050000, PR China.Department of Geriatrics, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei 050000, PR China; Department of Neurology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei 050000, PR China. · pubmed

Paper

Abstract

Age-related cognitive decline is associated with chronic neuroinflammation, and α-lipoic acid (LA) has been proposed as a potential cognitive enhancer. This study aimed to investigate whether LA ameliorates aging-related cognitive impairment by regulating neuroinflammation through the Peroxisome proliferator-activated receptor gamma (PPARγ)/nuclear factor kappa B (NF-κB) pathway in vivo and vitro.

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Research summary

The paper claims that α-lipoic acid mitigates age-related cognitive decline by modulating neuroinflammation through the PPARγ/NF-κB pathway. This research is relevant as it addresses the underlying mechanisms of neuroinflammation associated with aging, which is a significant factor in cognitive decline and longevity.

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