Subspace-located catalase prevents membrane degradation and dyssynchronization of local calcium release in adult cardiomyocytes.

Pasi Tavi, Nikolay Naumenko, Maija Mutikainen, Theresa Mader, Daniel C Andersson, Arturo Eu Gonzalez, Tomi Tuomainen, Johanna T Lanner

A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland. Electronic address: [email protected]. · pubmed

Paper

Abstract

Catalase, a canonical antioxidant enzyme, has been shown to prevent maladaptive oxidative damage and protect against aging-associated deterioration of cellular functions. In cardiac tissue, catalase protects cardiac myocytes against a variety of pathological changes by maintaining normal contractile function. Here we elucidated how catalase can protect cardiomyocyte excitation-contraction (EC) coupling we focused on exploring the subcellular location and specific effects of catalase in cardiomyocytes. To determine the effects of catalase on cardiomyocyte EC-coupling, we used adenoviral overexpression and pharmacological inhibition of catalase with 3AT in cultured adult mouse ventricular myocytes combined with detailed characterization of Ca

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

Catalase protects cardiomyocyte excitation-contraction coupling by preventing oxidative damage. The study addresses the role of oxidative stress in cardiac aging, which is a significant factor in the deterioration of cellular functions associated with aging.

Author of this paper? Send a correction.