The mitochondrial side of frailty.
Abstract
Frailty, a prevalent geriatric condition marked by reduced physiological reserve and greater vulnerability to stressors, is increasingly linked to mitochondrial dysfunction. This review summarizes current evidence on mitochondrial quality control, bioenergetics, and signaling in frailty, with emphasis on biomarker discovery and translational potential.
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Research summary
Mitochondrial dysfunction is implicated in the frailty of older adults, suggesting potential biomarkers and therapeutic targets. The paper addresses mitochondrial dysfunction as a root cause of frailty, linking it to broader implications for aging and longevity.
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