Environmental factors accelerate epigenetic aging of sperm via mechanistic target of rapamycin/blood-testis barrier mechanism.

Olatunbosun Arowolo, Oladele A Oluwayiose, Jiahui Zhu, Oleg Sergeyev, Emily Houle, J Richard Pilsner, Alexander Suvorov

Department of Environmental Health Sciences, School of Public Health and Health Sciences, University of Massachusetts Amherst, 686 N. Pleasant Str., Amherst, Massachusetts.Department of Environmental Health Sciences, School of Public Health and Health Sciences, University of Massachusetts Amherst, 686 N. Pleasant Str., Amherst, Massachusetts. · pubmed

Paper

Abstract

To identify a common molecular mechanism of sperm epigenome reprograming by environmental factors by testing whether mechanistic target of rapamycin (mTOR)-dependent and mTOR-independent disruption of the blood-testis barrier (BTB) by environmental factors (heat stress [HS] and cadmium [Cd] exposure, respectively) accelerate epigenetic aging of sperm in a mouse model.

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Research summary

The paper claims that environmental factors accelerate epigenetic aging of sperm through mTOR-dependent and mTOR-independent mechanisms. This research is relevant as it explores the underlying mechanisms of epigenetic aging, which is a critical aspect of understanding and potentially mitigating the aging process.

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