Baicalein Induces Hepatic Stellate Cell Senescence and Attenuates Liver Fibrosis via CEBPZ/p53/HK2-Mediated Glycolysis Inhibition.

Shuling Chen, Ruiqi Li, Caiyun Zhang, Jun Guo, Anyin Yang, Dawei Yang, Tianhao Mao, Hongli Liu, Hao Ren, Zihao Liang, Wei Chen, Changhua Yi, Qingfang Xiong, Dandan Yin, Xixuan Wang, Yongfeng Yang

Department of Hepatology, The Second Hospital of Nanjing, Affiliated to Nanjing University of Chinese Medicine, Nanjing 210000, Jiangsu, China; Department of Pharmacy, The Second Hospital of Nanjing, Affiliated to Nanjing University of Chinese Medicine, Nanjing, 210000, China. · pubmed

Paper

Abstract

Liver fibrosis progresses to life-threatening cirrhosis, yet effective therapies remain limited. Baicalein (BA), a bioactive flavonoid, shows anti-tumor potential but its anti-liver-fibrotic efficacy is completely unexplored.

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Research summary

Baicalein induces senescence in hepatic stellate cells and inhibits glycolysis to attenuate liver fibrosis. The study addresses liver fibrosis, a condition associated with aging, and explores a potential therapeutic approach that could impact age-related liver diseases.

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