GHSR suppression in neurons protects against aging-associated metabolic and cognitive impairments.

Hongying Wang, Chia-Shan Wu, Danilo Landrock, Ariel Nevarez, Shanrun Liu, Anna Thalacker-Mercer, Yanfeng Zhang, Jamie I Baum, Sunja Kim, Bingzhong Xue, Yuxiang Sun

Department of Nutrition, Texas A&M University, College Station, TX, 77843, USA.Department of Nutrition, Texas A&M University, College Station, TX, 77843, USA. · pubmed

Paper

Abstract

Aging is accompanied by progressive declines in metabolic and cognitive functions. Growth hormone secretagogue receptor (GHSR), a receptor for the gut hormone ghrelin, is highly expressed in neurons and plays a crucial role in metabolic regulation. We previously reported that aged global GHSR-ablated mice are lean and insulin-sensitive, and that neuronal GHSR-deleted mice (Syn1-cre;Ghsr

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Research summary

The paper claims that suppression of GHSR in neurons can protect against aging-associated metabolic and cognitive impairments. This research addresses mechanisms related to metabolic regulation and cognitive decline in aging, which are central to understanding and potentially mitigating the effects of aging.

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