ROS-degradable hydrogel delivering LOXL2-LNPs rescues disc degeneration by synchronously suppressing cellular senescence and oxidative damage.

Jian Zhang, Yang Li, Rui Ding, Chongzhi Pan, Jiajun Xie, Guanfeng Huang, Xiaolong Chen, Xiaokun Zhao, Xinxin Miao, Xigao Cheng

Department of Orthopedics, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, 330006, Jiangxi, China.Department of Orthopedics, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, 330006, Jiangxi, China. · pubmed

Paper

Abstract

Intervertebral disc degeneration (IDD) is a chronic degenerative disorder marked by nucleus pulposus cells (NPCs) senescence and extracellular matrix (ECM) degradation, which is a key pathological factor leading to low back pain. Current clinical treatments are mainly limited to symptomatic relief without effectively reversing the degenerative process.

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Research summary

The paper claims that a ROS-degradable hydrogel delivering LOXL2-LNPs can rescue disc degeneration by suppressing cellular senescence and oxidative damage. This research addresses the underlying mechanisms of intervertebral disc degeneration, which is related to aging processes and cellular senescence, thus contributing to the understanding of age-related degeneration.

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