Gut microbiota remodelling alleviates elderly sepsis by microbiota-derived acetic acid via FFAR2/NLRP3 pathway.

Guangwei Yu, Wenhui Xie, Jingnan Xiang, Yilang Ke, Zhuolin Wang, Fuquan Tu, Wenwei Wu, Huashan Hong, Xiaohong Lin

Department of Emergency, Fujian Medical University Union Hospital, Fuzhou, China; Fujian Key Laboratory of Vascular Aging, Fujian Medical University, Fuzhou, China.Department of Emergency, Fujian Medical University Union Hospital, Fuzhou, China; Fujian Key Laboratory of Vascular Aging, Fujian Medical University, Fuzhou, China. · pubmed

Paper

Abstract

Elderly patients with sepsis have higher morbidity, mortality, and susceptibility than adults. Young-donor faecal microbiota transplantation (FMT) can remodel and improve intestinal dysbiosis to alleviate age-related diseases via microbiota-derived acetic acid and may be a treatment option for elderly sepsis. This study aimed to elucidate the influence of remodelling of the elderly gut microbiota on sepsis via acetic acid and explore the underlying mechanism. We analyzed the gut microbiota and plasma acetic acid in elderly patients with sepsis, performed young-donor FMT, and acetic acid supplementation in a caecum ligation and puncture-induced aged septic model mice, and assessed the effects of acetic acid on the septic myocardium by examining NLRP3 inflammasome in FFAR2 knockdown mice.

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper claims that gut microbiota remodelling through microbiota-derived acetic acid can alleviate sepsis in elderly patients. This research is relevant as it explores potential interventions targeting gut microbiota to address age-related dysbiosis and its implications for improving health outcomes in the elderly, which aligns with longevity research.

Author of this paper? Send a correction.