Transcriptomic analysis demonstrates moderators of muscle quality are altered in age-related sarcopenic obesity.

Eleanor R Schrems, Ana Regina Cabrera, Ronald G Jones, Francielly Morena, Kevin A Murach, Nicholas P Greene, Tyrone A Washington

Exercise Muscle Biology Laboratory, Exercise Science Research Center, Department of Health, Human Performance and Recreation, University of Arkansas, 155 Stadium Dr. HPER 308W, Fayetteville, AR, 72701, USA.Exercise Muscle Biology Laboratory, Exercise Science Research Center, Department of Health, Human Performance and Recreation, University of Arkansas, 155 Stadium Dr. HPER 308W, Fayetteville, AR, 72701, USA. · pubmed

Paper

Abstract

Sarcopenic obesity (SO) is the combined condition of sarcopenia and obesity, which commonly occurs in the older adult population. SO is associated with poor physical function, increased risk of musculoskeletal injury, and reduced quality of life and independence. Information on the molecular underpinnings of this condition is limited. The aim of this study was to provide a transcriptomic analysis characterizing SO induced by lifelong obesity and to provide a deeper understanding of the etiology of the condition.

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper claims that transcriptomic analysis reveals alterations in moderators of muscle quality in age-related sarcopenic obesity. This research is relevant as it investigates the molecular mechanisms underlying a condition that affects physical function and quality of life in older adults, contributing to our understanding of age-related diseases.

Author of this paper? Send a correction.