Kai-Xin-San improves aging and associated neuroinflammation through mitochondrial autophagy.

Yu Gao, Jinxue Zhang, Xiaoqian Zhang, Chengjie Xing, Pengfei Xie, Zhenfei Zhou, Ting Zhan, Hanrui Zeng, Yang Wang, Yuanxu Liu, Caiyun Zhang

School of Pharmacy, Center for Xin'an Medicine and Modernization of Traditional Chinese Medicine of IHM, Anhui University of Chinese Medicine, Hefei, 230012, Anhui, China; Anhui Province Key Laboratory of Pharmaceutical Preparation Technology and Application, Institute of Pharmacokinetics, Hefei, 230012, Anhui, China; Engineering Technology Research Center of Modernized Pharmaceutics, Anhui Education Department (AUCM), Hefei, 230012, Anhui, China; Anhui Academy of Chinese Medicine, Anhui Genuine Chinese Medicinal Materials Quality Improvement Collaborative Innovation Center, Hefei, 230012, Anhui, China. Electronic address: [email protected] of Pharmacy, Center for Xin'an Medicine and Modernization of Traditional Chinese Medicine of IHM, Anhui University of Chinese Medicine, Hefei, 230012, Anhui, China; Anhui Province Key Laboratory of Pharmaceutical Preparation Technology and Application, Institute of Pharmacokinetics, Hefei, 230012, Anhui, China; Engineering Technology Research Center of Modernized Pharmaceutics, Anhui Education Department (AUCM), Hefei, 230012, Anhui, China; Anhui Academy of Chinese Medicine, Anhui Genuine Chinese Medicinal Materials Quality Improvement Collaborative Innovation Center, Hefei, 230012, Anhui, China. Electronic address: [email protected]. · pubmed

Paper

Abstract

Kai-Xin-San (KXS), a historically used traditional Chinese prescription, calms the mind, invigorates Qi, removes dampness and turbidity. Certain components of KXS have demonstrated anti-aging and anti-neuroinflammatory properties, but the underlying mechanisms of KXS as a whole remain unclear.

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Research summary

Kai-Xin-San improves aging and associated neuroinflammation through mitochondrial autophagy. The paper explores a traditional remedy that may address underlying mechanisms of aging and neuroinflammation, which are relevant to longevity research.

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