Ten mouse organs proteome and metabolome atlas from adult to aging.

Qingwen Wang, Zhixiao Xu, Xinwen Ding, Aiting Wang, Sunfengda Song, Shuang Zhang, Youming Chen, Yi Ding, Lai Jiang, Xianting Ding

Department of Anesthesiology and Surgical Intensive Care Unit, School of Medicine and School of Biomedical Engineering, Xinhua Hospital, Shanghai Jiao Tong University, Shanghai, China. · pubmed

Paper

Abstract

Aging is a complex biological process characterized by progressive molecular alterations across multiple organ systems, significantly influencing disease susceptibility and mortality. Unraveling molecular interactions driving aging is crucial for interventions promoting healthy aging and mitigating senescence. However, the systemic mechanisms governing both inter-organ interactions and organ-specific aging trajectories remain incompletely characterized.

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Research summary

The paper presents a comprehensive atlas of proteome and metabolome changes in mouse organs from adulthood to aging. This research is relevant as it aims to elucidate the molecular interactions and systemic mechanisms that drive aging, which is essential for developing interventions to promote healthy aging and address the root causes of age-related decline.

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