Diabetic kidney disease and aging: Focus on gut microbiota.

Jin Rong, Yuanhua Dai, Bo Zhang, Yuxi Li, Kexu Chen, Hanfei Li, Tingting Zhao, Shunmei Liu

College of Life Science and Technology, Shandong Second Medical University, Weifang, Shandong, 261053, China; The Institute of Clinical Medicine, State Key Laboratory of Respiratory Health and Multimorbidity, Beijing Key Laboratory of Critical Bridging Technologies for Chronic Disease Drug Development, China-Japan Friendship Hospital, Beijing, 100029, China.College of Life Science and Technology, Shandong Second Medical University, Weifang, Shandong, 261053, China; The Institute of Clinical Medicine, State Key Laboratory of Respiratory Health and Multimorbidity, Beijing Key Laboratory of Critical Bridging Technologies for Chronic Disease Drug Development, China-Japan Friendship Hospital, Beijing, 100029, China. · pubmed

Paper

Abstract

Diabetic kidney disease (DKD) is closely linked to aging, with gut microbiota imbalance recognized as a key factor, making it a growing research focus. Studies have shown that gut dysbiosis in DKD patients is characterized by a reduction in beneficial bacteria and an overgrowth of opportunistic pathogens, leading to gut barrier disruption, systemic low-grade inflammation, oxidative stress, and accelerated fibrosis. The decrease in short-chain fatty acids (SCFAs) impairs epigenetic regulation, driving the overexpression of fibrosis-related genes. Aging itself also alters the composition of the gut microbiota, further exacerbating metabolic disorders and inflammation, thereby creating a vicious cycle. This article aims to explore the potential roles and mechanisms of gut microbiota in the shared pathogenesis of DKD and aging, providing a theoretical foundation for the development of novel therapeutic interventions.

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Research summary

The paper claims that gut microbiota imbalance contributes to the pathogenesis of diabetic kidney disease and aging. This research explores mechanisms that could address underlying factors related to aging and metabolic disorders, making it relevant to longevity research.

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