The loss of a ClC anion channel increases life span, health span, and stress resistance by alkalinizing a pair of glial cells in
Abstract
Aging depends on genetic and environmental factors, but the specific cell types and mechanisms that coordinate aging of the entire organism are not yet fully understood. Glial cells regulate ionic homeostasis, which is essential for neuronal function and survival. Here, we investigated the role of glial ion channel CLH-1, which is a glial pH regulator, in aging. We found that loss of
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Research summary
The loss of the ClC anion channel in glial cells leads to increased lifespan, health span, and stress resistance. This research addresses a specific mechanism related to aging by exploring the role of glial cells in regulating pH and ionic homeostasis, which are crucial for understanding the biological processes of aging.
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