Translational regulation in stress biology.

Naomi R Genuth, Andrew Dillin

Department of Molecular and Cell Biology, University of California, Berkeley, CA, USA.Department of Molecular and Cell Biology, University of California, Berkeley, CA, USA. · pubmed

Paper

Abstract

Organisms must constantly respond to stress to maintain homeostasis, and the successful implementation of cellular stress responses is directly linked to lifespan regulation. In this Review we examine how three age-associated stressors-loss of proteostasis, oxidative damage and dysregulated nutrient sensing-alter protein synthesis. We describe how these stressors inflict cellular damage via their effects on translation and how translational changes can serve as both sensors and responses to the stressor. Finally, we compare stress-induced translational programmes to protein synthesis alterations that occur with age and discuss whether these changes are adaptive or deleterious to longevity and healthy ageing.

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper claims that alterations in translational regulation due to age-associated stressors can influence longevity and healthy aging. This research is relevant as it addresses the mechanisms of cellular stress responses and their direct link to lifespan regulation, which is central to understanding aging and potential interventions.

Author of this paper? Send a correction.