CD4 T cells acquire Eomesodermin to modulate cellular senescence and aging.

Yehezqel Elyahu, Ilana Feygin, Ekaterina Eremenko, Noa Pinkas, Alon Zemer, Amit Shicht, Omer Berner, Roni Avigdory-Meiri, Anna Nemirovsky, Keren Reshef, Lior Roitman, Valery Krizhanovsky, Alon Monsonego

The Shraga Segal Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel. · pubmed

Paper

Abstract

Aging is characterized by the progressive deterioration of tissue structure and function, leading to increased vulnerability to diseases. Senescent cells (SCs) accumulate with age, but how the immune system regulates their burden is unclear. Here we show that CD4 T cells differentiate into Eomesodermin (Eomes)

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Research summary

CD4 T cells differentiate into Eomesodermin to modulate cellular senescence and aging. This research addresses the immune system's role in regulating senescent cell accumulation, which is a key aspect of the aging process and its associated diseases.

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