Inflammaging and the sex-frailty paradox.

Beatrice Arosio, Greta Salafia, Evelyn Ferri, Daniela Mari, Eleonora Tobaldini, Giovanni Vitale, Nicola Montano

Department of Clinical Sciences and Community Health, Dipartimento di Eccellenza 2023-2027, University of Milan, Via della Commenda 19, Milan, 20122, Italy. [email protected] of Clinical Sciences and Community Health, Dipartimento di Eccellenza 2023-2027, University of Milan, Via della Commenda 19, Milan, 20122, Italy. [email protected]. · pubmed

Paper

Abstract

The "sex-frailty paradox" is a concept that indicates how women despite being more frail are less susceptible to death than men. The roots of this paradox may lie in the different combination of biological, behavioural, and social factors between the two sexes. The aim of this study is to deepen our understanding of the different biological mechanisms underlying frailty and longevity in men and women, thus shedding further light on the sex-frailty paradox.

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Research summary

The paper explores the biological mechanisms underlying the sex-frailty paradox in relation to longevity. This study is relevant as it addresses the biological differences in aging and frailty between sexes, which could contribute to understanding longevity and age-related health disparities.

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