Life's Essential 8, phenotypic age, and cardiovascular age in prediabetes: predictive value in the UK Biobank and protein mediation in cardiovascular-diabetes comorbidity.

Chaoping Chen, Chenhao Li, Qingru Zhu, Yang Yang, Sixiang Jia, Xiaojian Zhang, Shudong Xia

Department of Cardiology, The Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, 322000, China. · pubmed

Paper

Abstract

Lifestyle improvement may help reverse prediabetes. Indicators such as Life's Essential 8 (LE8) and biological aging measures (phenotypic age, cardiovascular biological age) partially reflect metabolic status in prediabetes, but their predictive value for cardiovascular mortality and stroke in this population remains unclear.

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Research summary

The paper investigates the predictive value of lifestyle indicators and biological aging measures in prediabetes for cardiovascular outcomes. The focus on lifestyle improvement and biological aging measures aligns with longevity research by addressing factors that may influence aging and age-related diseases.

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