Predominant role of fat mass in the association between HMB and frailty.

Begoña Molina-Baena, Jose Antonio Carnicero, Suzette L Pereira, Ricardo Rueda, Ángela Santos-Fandila, Alejandro Álvarez-Bustos, Francisco José García-García, Leocadio Rodríguez-Mañas

Department of Endocrinology and Nutrition, La Princesa University Hospital, Madrid, Spain. Universidad Autónoma de Madrid, Escuela de Doctorado.Department of Endocrinology and Nutrition, La Princesa University Hospital, Madrid, Spain. Universidad Autónoma de Madrid, Escuela de Doctorado. · pubmed

Paper

Abstract

β-hydroxy-β-methylbutyrate (HMB) is a bioactive metabolite formed from breakdown of leucine, which increases muscle protein synthesis and reduces muscle breakdown. Previous studies have shown an inverse association between HMB levels and frailty in older adults. This study aims to assess if body composition influences this association.

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Research summary

The paper claims that fat mass significantly influences the relationship between HMB levels and frailty in older adults. This research is relevant as it explores the role of body composition in frailty, a condition associated with aging, and could contribute to understanding factors that affect longevity and healthspan.

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