Capsosiphon fulvescens glycopeptides restore synaptic plasticity and mitigate cognitive decline via calcineurin regulation in aged hippocampus.
Abstract
Age-related cognitive decline and synaptic loss are associated with alterations in hippocampal synaptic protein phosphorylation and signaling pathways. Natural compounds from marine sources, such as Capsosiphon fulvescens glycopeptides (Cf-tPep), have shown potential neuroprotective properties. This study aimed to investigate the effects of trypsinized glycopeptides from C. fulvescens on synaptic protein phosphorylation and cognitive function in aging hippocampal neurons and rats.
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Research summary
Capsosiphon fulvescens glycopeptides can restore synaptic plasticity and mitigate cognitive decline in aged hippocampal neurons. The study addresses cognitive decline associated with aging, focusing on potential neuroprotective mechanisms that could contribute to understanding and possibly mitigating age-related cognitive decline.
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