Longitudinal changes in late-life brain health after prenatal exposure to the Dutch famine.

A Boots, A Schrantee, B E Padrela, A M Wiegersma, J S Damoiseaux, H J M M Mutsaerts, L Lorenzini, T J Roseboom, S R de Rooij

Amsterdam UMC location University of Amsterdam, Department of Epidemiology and Data Science, Amsterdam, the Netherlands; Aging and Later Life, Amsterdam Public Health, Amsterdam, the Netherlands; Amsterdam Reproduction and Development, Amsterdam, the Netherlands. Electronic address: [email protected]. · pubmed

Paper

Abstract

The consequences of harmful prenatal exposures for brain health may last a lifetime. Previous studies showed smaller adult brain volumes and altered perfusion at age 68 after prenatal famine exposure, particularly in men. To investigate whether the previously observed effects reflect persistent developmental effects or accelerated brain aging, we here studied longitudinal changes in brain volumes, white matter integrity, white matter hyperintensities and perfusion between ages 68 and 74 in individuals exposed and unexposed to famine in early gestation.

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Research summary

The paper investigates the longitudinal effects of prenatal famine exposure on brain health in late life. This research is relevant as it explores the long-term consequences of early-life environmental factors on aging and brain health, contributing to our understanding of the root causes of age-related changes.

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