Exploring causal relationships between epigenetic age acceleration and Alzheimer's disease: a bidirectional Mendelian randomization study.
Abstract
Alzheimer's disease (AD) is identified by a distinct progression of aging-associated cognitive and functional impairment. Recent advances recognize the DNA methylation-based epigenetic clock as a precise predictor of aging processes and their related health outcomes. However, observational studies exploring this link are often compromised by confounding factors and reverse causality bias. To address the question, our study employs a bidirectional Mendelian randomization (MR) analysis to explore the causal relationship between epigenetic age acceleration (EAA) and AD.
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Research summary
The paper claims to explore the causal relationship between epigenetic age acceleration and Alzheimer's disease using Mendelian randomization. This research is relevant as it investigates the underlying mechanisms of aging processes and their connection to age-related diseases, potentially contributing to a better understanding of aging itself.
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