Regulation of nuclear transport of the transcriptional factor REST improves axon regeneration in peripheral nerves.

Takamaru Suzuki, Kiyohito Naito, Daisuke Kubota, Yuji Ueno, Takako Negishi-Koga, Yasuhiro Yamamoto, So Kawakita, Norizumi Imazu, Kenjiro Kawamura, Nobutaka Hattori, Muneaki Ishijima

Department of Medicine for Orthopaedics and Motor Organ, Juntendo University Graduate School of Medicine, Tokyo 113‑8421, Japan. · pubmed

Paper

Abstract

The expression of repressor element 1 silencing transcription factor (REST) in peripheral nerves increases with age, which leads to a decline in axon regeneration. However, the detailed mechanisms behind the decline in axon regeneration with age remain to be elucidated. The present study investigated the mechanism of nuclear transport of REST using hydrogen (H

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper claims that regulating the nuclear transport of REST can improve axon regeneration in peripheral nerves. This research is relevant as it addresses a mechanism related to age-associated decline in regenerative capacity, which is a fundamental aspect of aging.

Author of this paper? Send a correction.