Ultraviolet-B Irradiation Induces miR-663a and miR-4706 Accelerated Photoaging by Targeting Sirtuin 6 in Human Dermal Fibroblasts.

Mengna Li, Meng Wang, Yi Li, Han Bai, Li Li, Baoxi Wang, Yan Yan

Department of Dermatology, Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.Department of Dermatology, Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. · pubmed

Paper

Abstract

Ultraviolet (UV) radiation contributes to premature skin aging, and sirtuin 6 (SIRT6) plays key roles in aging, genomic stability, inflammation, and metabolism. However, the specific role of SIRT6 in UV-induced photoaging remains unclear.

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Research summary

Ultraviolet-B irradiation induces miR-663a and miR-4706, which accelerate photoaging by targeting Sirtuin 6 in human dermal fibroblasts. This research addresses the mechanisms of photoaging, which is a significant aspect of the aging process and contributes to our understanding of longevity.

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