Enhanced Selenium Supplement Extends Lifespan and Delays Multi-Organs Aging by Regulating the Sik1 Pathway Through Maintaining Calcium Homeostasis.

Yang Yu, Jintao Song, Mengjiao Guo, RuZe Ma, Mingyang Du, Zhe Xun, Xu Liu, RongXia Xu, Xiaochun Xie, Peilin Qi, Yujie Chen, Dan Shao, Chao Yang, Liang Wang, Xiaoyu Song, Difei Wang

Health Sciences Institute, China Medical University, Shenyang, Liaoning, 110122, China.Health Sciences Institute, China Medical University, Shenyang, Liaoning, 110122, China. · pubmed

Paper

Abstract

Selenium supplementation has potential in treating aging-related disorders like neurodegenerative and cardiovascular diseases, but its use is limited by poor bioavailability, a narrow therapeutic window, and unclear mechanisms. To overcome this, redox-dual-responsive diselenide-bridged mesoporous silica nanoparticles (SeMSNs) are developed. SeMSNs effectively reduce oxidative stress and downregulate senescence markers (p16, p21), suppressing senescence in both naturally aged primary mouse embryonic fibroblasts (MEFs) and H

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Research summary

The paper claims that enhanced selenium supplementation via SeMSNs can extend lifespan and delay aging by regulating the Sik1 pathway and maintaining calcium homeostasis. This research is relevant as it addresses mechanisms that could potentially mitigate the aging process and improve longevity rather than merely treating age-related diseases.

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