Resistance Exercise Intervention Restores Functional Capacity and Improves Frailty Biomarkers in Centenarians.

Diego Marcos-Perez, Adrián Hernandez-Vicente, Sara Cruces-Salguero, Jon Landa, Michelle Bonvini, German Vicente-Rodríguez, Esther Pueyo, Leocadio Rodriguez-Mañas, Pedro Abizanda, David Otaegui, Nuria Garatachea, Ander Matheu

Cellular Oncology Group, Biodonostia (Biogipuzkoa) Health Research Institute, San Sebastián, Spain.Cellular Oncology Group, Biodonostia (Biogipuzkoa) Health Research Institute, San Sebastián, Spain. · pubmed

Paper

Abstract

Centenarians comprise an age group characterized by exceptional longevity and low age-associated pathologies. However, they still experience physiological decline, and different studies have linked frailty to this population. Exercise interventions reverse frailty and improve functional capacity, but no studies have addressed the effect of an intervention in centenarians. In this study, we assessed the impact of a 12-week resistance exercise intervention in a group of centenarians and characterized their functional capacity as well as the expression of several molecular biomarkers associated with frailty.

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Research summary

A 12-week resistance exercise intervention can improve functional capacity and frailty biomarkers in centenarians. This study is relevant as it addresses the physiological decline associated with aging and explores an intervention that may enhance longevity and quality of life in an exceptionally aged population.

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