Klotho, Kidneys, and Micronutrient Signaling: A Promising Paradigm for Healthy Aging.
Abstract
Klotho, a transmembrane protein with pleiotropic antiaging properties, is increasingly recognized as a central regulator of longevity and metabolic resilience. Primarily expressed in the kidneys and brain, Klotho governs phosphate and calcium homeostasis, modulates redox signaling, and influences key metabolic pathways, including PI3K/AKT and IGF-1. Declining Klotho expression is associated with both biological and chronological aging and has been mechanistically implicated in the pathogenesis of chronic kidney disease, cardiovascular disease, neurodegeneration, and metabolic dysfunction.
The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.
Research summary
Klotho is a central regulator of longevity and metabolic resilience, influencing key pathways associated with aging. The paper is relevant as it addresses the role of Klotho in aging mechanisms and its potential implications for longevity and age-related diseases.
Author of this paper? Send a correction.