Spatial Mass Spectrometry-Based Proteomic Analysis of Normal-Appearing Glomeruli from Young and Old Adults.

Kiran K Mangalaparthi, Gunveen S Sachdeva, Afsana Ansari Shaik, Shilpa Venkataraman, Aidan F Mullan, Ganesh P Pujari, Benjamin J Madden, Muhammad Sohaib Asghar, Vidit Sharma, Mariam P Alexander, Nicholas B Larson, Aleksandar Denic, Akhilesh Pandey, Andrew D Rule

Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA. · pubmed

Paper

Abstract

Kidney aging is characterized by a loss of glomeruli, predominately in the superficial cortex, with a resultant decline in glomerular filtration rate and an increased risk of various kidney-related diseases. The early molecular alterations in glomeruli associated with the aging process are not well studied.

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Research summary

The paper investigates the molecular alterations in glomeruli associated with aging. This research is relevant as it addresses the biological mechanisms underlying kidney aging, which could contribute to understanding the root causes of age-related decline in kidney function.

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