Proteomic aging clocks and the risk of mortality among long-term cancer survivors.

Shuo Wang, Zexi Rao, Anne H Blaes, Josef Coresh, Corinne E Joshu, James S Pankow, Bharat Thyagarajan, Ruth Dubin, Rajat Deo, Seamus P Whelton, Michael J Blaha, Catherine H Marshall, Jerome I Rotter, Peter Ganz, Weihua Guan, Elizabeth A Platz, Anna Prizment

Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA. · pubmed

Paper

Abstract

To estimate biological age, we developed a proteomic aging clock in cancer-free participants (CaPAC) and examined its association with mortality in long-term cancer survivors (LTCS, >2 years between cancer diagnosis and blood collection) and cancer-free participants in the Atherosclerosis Risk in Communities (ARIC) and Multi-Ethnic Study of Atherosclerosis (MESA) studies.

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Research summary

The paper claims that a proteomic aging clock can predict mortality risk among long-term cancer survivors. This research is relevant as it explores biological aging markers, which are crucial for understanding longevity and age-related health outcomes.

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