Nucleolar stress facilitates islet β cell senescence via hijacking the DNA damage response pathways.

Yaqi Jiao, Weirong Lu, Xiaohua Wang, Wenxing Sun, Baoying Hu, Jianya Zhao, Jinghao Fang, Ying Lu, Chunhua Wan

Department of Nutrition and Food Hygiene, School of Public Health, Nantong University, Nantong, Jiangsu 226019, China.Department of Nutrition and Food Hygiene, School of Public Health, Nantong University, Nantong, Jiangsu 226019, China. · pubmed

Paper

Abstract

Senescence is a crucial contributor to pancreatic β cell dysfunction during diabetes progression. Herein, we demonstrated that nucleolar stress, a stress event resulting from disrupted ribosomal RNA (rRNA) synthesis, drives β cell senescence. Senescent β cells exhibited altered nucleolar morphology and redistribution of the nucleolar protein nucleophosmin (NPM)

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Research summary

Nucleolar stress drives β cell senescence through the hijacking of DNA damage response pathways. This research addresses a mechanism contributing to cellular senescence, which is a key factor in aging and age-related diseases, particularly in the context of diabetes.

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