The role of miR-217/SIRT1 Axis in modulating the NLRP3 Inflammasome in the naturally aging thoracic aorta and in endothelial cells undergoing senescence induced by H

Dake Huang, Ke Shen, Li Gui, Qiongqiong Cao, Fangmei Yu, Yunxia Lu

The Comprehensive Experiment Center, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Anhui Medical University, No. 81, Meishan Road, Hefei, China. · pubmed

Paper

Abstract

Given resveratrol's (RES) potential as an anti-aging agent, this study explored its ability to inhibit the NOD-, LRR-, and pyrin domain-containing protein 3 (NLRP3) inflammasome through the miR-217/SIRT1 axis in senescent endothelial cells. Male C57BL/6 mice were administered a customized regular diet supplemented with 0.04 % RES for 64 consecutive weeks. Subsequently, the effects of RES on senescent human umbilical vein endothelial cells (HUVECs) induced by H

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Research summary

The study claims that resveratrol inhibits the NLRP3 inflammasome through the miR-217/SIRT1 axis in senescent endothelial cells. This research addresses mechanisms related to aging and inflammation, which are central to understanding and potentially mitigating age-related diseases.

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