Cumulative Epigenetic Aging From Birth to Young Adulthood and Prospective Associations With Cardiometabolic Health in the CHAMACOS Study.

Saher Daredia, Corinne A Riddell, Dennis Khodasevich, Anne K Bozack, Kim G Harley, Katherine R Kogut, Ana M Mora, Nina Holland, Brenda Eskenazi, Julianna Deardorff, Andres Cardenas

Division of Epidemiology, School of Public Health University of California Berkeley CA USA.Division of Epidemiology, School of Public Health University of California Berkeley CA USA. · pubmed

Paper

Abstract

Epigenetic modifications linked to biological aging, like DNA methylation (DNAm), may serve as biomarkers for future cardiometabolic disease risk. However, existing studies have focused on older adults, overlooking the early-life origins of cardiometabolic health.

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Research summary

Cumulative epigenetic aging from birth to young adulthood is associated with future cardiometabolic health risks. This paper is relevant as it explores early-life epigenetic modifications that may influence long-term health outcomes, addressing the origins of aging-related diseases.

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