MSCs-derived HGF alleviates senescence after AKI by modulating mitoSTAT3-controlled copper flux and respiration.

Kaiting Zhuang, Wenjuan Wang, Cheng Xu, Siyang Wang, Yuhao Chen, Yingjie Zhang, Yanjun Liang, Xumin Zheng, Xiangmei Chen, Zhe Feng, Guangyan Cai

Department of Nephrology, First Medical Center of Chinese PLA General Hospital, National Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing Key Laboratory of Kidney Diseases Research, Beijing, 100853, China.Department of Nephrology, First Medical Center of Chinese PLA General Hospital, National Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing Key Laboratory of Kidney Diseases Research, Beijing, 100853, China. · pubmed

Paper

Abstract

Human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) can reverse senescence after acute kidney injury (AKI) via maintaining mitochondrial homeostasis. Copper accumulation and STAT3 nuclear translocation promote senescence, but their mitochondrial localization in response to MSCs remains unclear.

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper claims that MSCs-derived HGF can alleviate senescence after AKI by modulating mitoSTAT3-controlled copper flux and respiration. This research is relevant as it addresses mechanisms that may contribute to cellular senescence, a key factor in aging and age-related diseases.

Author of this paper? Send a correction.